No. I never had any issues with larger soda bottles. I would usually buy the 1 or 1.5 liter bottles because they were usually the best deal.
I did some sales work for one of the local soda distributors, and it was crazy how much better the 20oz bottles did in comparison to everything else.
It was the same with energy drinks. Most people would buy single cans for $3 when they could get a 4 pack for $10 or a 12 pack for $20.
We would usually just open the 12 packs at our accounts because the singles simply sold better.
22 billion is just a drop in the bucket to the Committee of 300 on their path to world domination.